Turck Dominique
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lille University Children's Hospital and Faculty of Medicine, Hôpital Jeanne de Flandre, 2 avenue Oscar Lambret, 59037 Lille cedex, France.
Curr Opin Clin Nutr Metab Care. 2007 May;10(3):360-5. doi: 10.1097/MCO.0b013e3280fa821b.
This review discusses the safety, nutritional adequacy and recommendations for use of soy protein formulae, based mainly on the most relevant reports published during 2005 and 2006.
Concerns have recently been raised regarding potential risks with soy protein formulae, in particular regarding their high phytoestrogenic isoflavone content. Recent data are insufficient to draw definitive conclusions on safety, but authorities and paediatric societies from several countries recently advised health professionals to use soy protein formulae only in certain cases. Indications for use of soy protein formulae, mainly for prevention and management of food allergy, have also been better defined.
Soy protein formulae ensure normal growth and development in healthy term infants but they have no nutritional advantages over cow's milk protein formulae. Main indications include severe lactose intolerance, galactosaemia and need to avoid foods of animal origin. Soy protein formulae have no role in preventing allergy or in management of nonspecific gastrointestinal symptoms (e.g. infantile colic and regurgitation). They should not be used in preterm infants or infants with food allergy before age 6 months. After 6 months, soy protein formulae may be considered if tolerance to soy protein is established.
本综述主要基于2005年至2006年期间发表的最相关报告，探讨大豆蛋白配方奶粉的安全性、营养充足性及使用建议。
近期有人对大豆蛋白配方奶粉的潜在风险提出担忧，尤其是其高含量的植物雌激素异黄酮。目前的数据不足以就安全性得出明确结论，但一些国家的当局和儿科学会最近建议健康专业人员仅在某些情况下使用大豆蛋白配方奶粉。大豆蛋白配方奶粉的使用指征，主要用于预防和管理食物过敏，也得到了更明确的界定。
大豆蛋白配方奶粉可确保健康足月儿正常生长发育，但与牛奶蛋白配方奶粉相比并无营养优势。主要指征包括严重乳糖不耐受、半乳糖血症以及需要避免食用动物源性食物。大豆蛋白配方奶粉在预防过敏或管理非特异性胃肠道症状（如婴儿腹绞痛和反流）方面并无作用。不应在早产儿或6个月以下有食物过敏的婴儿中使用。6个月后，如果已建立对大豆蛋白的耐受性，可考虑使用大豆蛋白配方奶粉。
