Yoshida S, Endo S, Tomita H
Department of Otorhinolaryngology, Nihon University School of Medicine, Tokyo, Japan.
Auris Nasus Larynx. 1991;18(2):153-61. doi: 10.1016/s0385-8146(12)80219-7.
The therapeutic efficacy of orally given zinc gluconate on taste disorder was investigated by a double-blind study in 98 patients with a chief complaint of this disease. The subjects were divided into two 49-patient groups and were orally given zinc gluconate or the placebo for up to 4 months. Improvement of taste examination and subjective symptoms was analyzed in 65 of the subjects. Although no significant difference was detected between the two groups in overall efficacy, a significant superiority of zinc gluconate to placebo was observed in patients with idiopathic and zinc-deficient taste disorder. Comparison of the improvement by Ridit analysis showed a significant therapeutic superiority of zinc gluconate. In contrast, comparison of the degree of subjective symptomatic changes.
通过一项双盲研究，对98例以味觉障碍为主诉的患者口服葡萄糖酸锌的治疗效果进行了调查。受试者被分为两个各有49名患者的组，分别口服葡萄糖酸锌或安慰剂，为期4个月。对65名受试者的味觉检查和主观症状改善情况进行了分析。尽管两组在总体疗效上未检测到显著差异，但在特发性和缺锌性味觉障碍患者中，观察到葡萄糖酸锌相对于安慰剂有显著优势。通过Ridit分析比较改善情况显示，葡萄糖酸锌具有显著的治疗优势。相比之下，对主观症状变化程度进行比较。
