在一项双盲研究中，葡萄糖酸锌含片可缩短普通感冒的病程。
Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study.
作者信息
Eby G A, Davis D R, Halcomb W W
出版信息
Antimicrob Agents Chemother. 1984 Jan;25(1):20-4. doi: 10.1128/AAC.25.1.20.
Abstract
As a possible treatment for common colds, we tested zinc gluconate lozenges in a double-blind, placebo-controlled, clinical trial. One 23-mg zinc lozenge or matched placebo was dissolved in the mouth every 2 wakeful h after an initial double dose. After 7 days, 86% of 37 zinc-treated subjects were asymptomatic, compared with only 46% of 28 placebo-treated subjects (P = 0.0005). Side effects or complaints were usually minor and consisted mainly of objectionable taste and mouth irritation. Zinc lozenges shortened the average duration of common colds by about 7 days.
摘要
作为普通感冒的一种可能治疗方法，我们在一项双盲、安慰剂对照的临床试验中对葡萄糖酸锌含片进行了测试。在初始双倍剂量后，每清醒2小时在口中溶解一片23毫克的锌含片或匹配的安慰剂。7天后，37名接受锌治疗的受试者中有86%无症状，而28名接受安慰剂治疗的受试者中只有46%无症状（P = 0.0005）。副作用或不适通常较轻，主要包括味道不佳和口腔刺激。锌含片使普通感冒的平均持续时间缩短了约7天。
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本文引用的文献
1
Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects.口服补充锌对正常受试者淋巴细胞对有丝分裂原反应的影响。
Am J Clin Nutr. 1981 Jan;34(1):88-93. doi: 10.1093/ajcn/34.1.88.
2
Topical treatment of recurrent herpes simplex and post-herpetic erythema multiforme with low concentrations of zinc sulphate solution.低浓度硫酸锌溶液局部治疗复发性单纯疱疹和疱疹后多形红斑。
Br J Dermatol. 1981 Feb;104(2):191-4. doi: 10.1111/j.1365-2133.1981.tb00044.x.
3
Beneficial effects of oral zinc supplementation on the immune response of old people.
Am J Med. 1981 May;70(5):1001-4. doi: 10.1016/0002-9343(81)90849-4.
4
5
Topical application of zinc-solutions: a new treatment for herpes simplex infections of the skin?
Acta Derm Venereol. 1980;60(2):175-77.
6
Histamine activates suppressor cells in vitro using a coculture technique.组胺利用共培养技术在体外激活抑制细胞。
J Clin Immunol. 1981 Jan;1(1):73-9. doi: 10.1007/BF00915479.
7
Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.锌离子存在下产生的大微小核糖核酸病毒多肽的特性分析。
J Virol. 1974 Aug;14(2):282-91. doi: 10.1128/JVI.14.2.282-291.1974.
8
Zinc ions inhibit replication of rhinoviruses.锌离子抑制鼻病毒的复制。
Nature. 1974 Apr 12;248(449):588-90. doi: 10.1038/248588a0.
9
Acceleration of wound healing in man with zinc sulphate given by mouth.口服硫酸锌对人体伤口愈合的促进作用。
Lancet. 1967 Jan 21;1(7482):121-4. doi: 10.1016/s0140-6736(67)91031-8.
10
Distribution and removal of human serum albumin-technetium 99m instilled intranasally.经鼻滴注的99m锝标记人血清白蛋白的分布与清除
Br J Clin Pharmacol. 1976 Oct;3(5):869-78. doi: 10.1111/j.1365-2125.1976.tb00640.x.
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