Rubin Bruce K
Pediatrics and Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1081, USA.
Paediatr Respir Rev. 2007 Mar;8(1):4-7. doi: 10.1016/j.prrv.2007.02.004. Epub 2007 Mar 21.
The biophysical properties of airway secretions are largely determined by the polymeric components. In normal airway mucus, the gel-forming mucins, MUC5AC and MUC5B, are responsible not only for the viscoelastic properties essential for clearance and protecting the airway epithelium from invaders and water evaporation. With chronic airway infection, inflammatory cell necrosis leads to a predominance of polymeric DNA and F-actin. There is almost no mucin in the sputum of patients with established cystic fibrosis lung disease. Sputum viscoelastic and surface properties determine how well secretions can be cleared by cilia or cough. In this mini-Symposium on Airway Clearance in Cystic Fibrosis, the physiology of CF secretion structure and rheology is discussed in the context of medications and physical maneuvers for enhancing sputum clearance.
气道分泌物的生物物理特性很大程度上由聚合物成分决定。在正常气道黏液中，形成凝胶的黏蛋白MUC5AC和MUC5B不仅负责维持黏液的黏弹性，这种特性对于清除气道分泌物、保护气道上皮免受病原体入侵以及防止水分蒸发至关重要。慢性气道感染时，炎症细胞坏死导致聚合物DNA和F-肌动蛋白占主导。在已确诊的囊性纤维化肺病患者的痰液中几乎没有黏蛋白。痰液的黏弹性和表面特性决定了分泌物通过纤毛运动或咳嗽清除的效果。在本次关于囊性纤维化气道清除的小型研讨会上，将在促进痰液清除的药物和物理手段的背景下讨论囊性纤维化分泌物的结构和流变学生理。
