Johnstone I B, Crane S
Can Vet J. 1981 Aug;22(8):239-43.
The history, clinical symptoms and laboratory results in two families of Doberman pinschers with von Willebrand's disease are described. The affected animals illustrate the rather nonspecific bleeding problems that may be encountered in mild and moderate forms of this disease. In both families a bleeding diathesis was suspected when one member of the family underwent surgery with serious postoperative bleeding complications. These cases illustrate the importance of a thorough presurgical history as well as the necessity for specific laboratory assays of F VIII including von Willebrand factor activity for the recognition of affected and "carrier" animals.
本文描述了两个患有血管性血友病的杜宾犬家族的病史、临床症状和实验室检查结果。患病动物表现出了这种疾病轻度和中度形式可能出现的相当非特异性的出血问题。在这两个家族中，当家族中的一个成员接受手术后出现严重的术后出血并发症时，怀疑存在出血素质。这些病例说明了全面的术前病史的重要性，以及对包括血管性血友病因子活性在内的F VIII进行特定实验室检测以识别患病动物和“携带者”动物的必要性。
