Steiss J E, Naylor J M
Can Vet J. 1986 Sep;27(9):332-5.
A three year old Quarter Horse stallion was presented with a one year history of episodes of generalized muscle tremors and stiffness, and spasm of the muscles of facial expression, lasting 10-15 minutes. Between attacks, the horse was either normal or had a localized muscle tremor in the flank region. Episodes appeared unrelated to exercise. The major abnormal findings included 1) a rise in plasma potassium from a resting level of 4.4 to 7.9 mmol/L during an attack and 2) electromyographic findings of generalized increased insertion activity and myotonic discharges. The horse was treated with hydrochlorothiazide tablets for nine months, during which time no further attacks were noted. However, four months after the drug was stopped, sporadic focal muscle tremors reappeared; two months later, generalized attacks were seen. Despite reinstitution of the diuretic, a focal flank tremor persisted. Two related horses in the same stable also were reported by the owner to exhibit sporadic generalized muscle twitching. The abnormal findings of the present case differ from clinical syndromes previously reported in horses. Some similarities to hyperkalemic periodic paralysis in humans are noted.
一匹三岁的夸特马种公马，有一年的全身肌肉震颤、僵硬及面部表情肌痉挛病史，发作持续10 - 15分钟。发作间歇期，马要么正常，要么胁腹区域有局部肌肉震颤。发作似乎与运动无关。主要异常发现包括：1）发作期间血浆钾从静息水平4.4 mmol/L升至7.9 mmol/L；2）肌电图显示全身插入活动增加和强直放电。这匹马用氢氯噻嗪片治疗了九个月，在此期间未再出现发作。然而，停药四个月后，散在的局部肌肉震颤再次出现；两个月后，出现全身发作。尽管重新使用了利尿剂，但胁腹局部震颤持续存在。同一马厩中另外两匹相关的马，主人报告也表现出散在的全身肌肉抽搐。本病例的异常发现与先前报道的马的临床综合征不同。注意到与人类高钾性周期性麻痹有一些相似之处。
