Dabelsteen E, Mandel U, Clausen H
Royal Dental College, Copenhagen, Denmark.
Crit Rev Oral Biol Med. 1991;2(4):493-507. doi: 10.1177/10454411910020040301.
Carbohydrates of the epithelial cell membrane are involved in cell-cell and cell-substrate interaction, and changes are seen in relationship to cell differentiation and neoplastic transformation. The terminal part of carbohydrate structures carried on oral epithelial cells often expresses antigens of the ABO and Lewis blood group systems. The expression of these antigens are in oral mucosa genetically regulated by the A, B, H, Lewis, and secretor genes with subsequent correspondence between the blood group antigens expressed on erythrocytes and on oral epithelial cells. Variation in expression of carbohydrates is also seen in relationship to terminal differentiation in that blood group antigens and their immediate precursor structures are sequentially expressed on cells during their pathway through the epithelium. Various organs and tissues differ in their expression of cell surface carbohydrates. In oral mucosa, a close relationship is seen between the type of tissue differentiation and expression of blood group antigen; keratinized, nonkeratinized, and junctional epithelium all show different patterns of carbohydrate expression.
上皮细胞膜中的碳水化合物参与细胞间和细胞与基质间的相互作用，并且在细胞分化和肿瘤转化方面会出现变化。口腔上皮细胞所携带的碳水化合物结构的末端部分通常表达ABO和Lewis血型系统的抗原。这些抗原的表达在口腔黏膜中受A、B、H、Lewis和分泌型基因的遗传调控，随后红细胞和口腔上皮细胞上表达的血型抗原之间存在对应关系。碳水化合物表达的变化在终末分化方面也有体现，即血型抗原及其直接前体结构在细胞穿过上皮的过程中会在细胞上依次表达。各种器官和组织在细胞表面碳水化合物的表达上存在差异。在口腔黏膜中，组织分化类型与血型抗原的表达之间存在密切关系；角化上皮、非角化上皮和结合上皮均呈现出不同的碳水化合物表达模式。
