评估尿N1,N12 - 二乙酰精胺作为膀胱癌潜在肿瘤标志物的作用。
Evaluation of urine N1,N12-Diacetylspermine as potential tumor marker for urinary bladder cancer.
作者信息
Stejskal David, Humenanska Viera, Hanulova Zuzana, Fiala Richard, Vrtal Radovan, Solichova Pavlina, Karpisek Michal
机构信息
Department of Laboratory Medicine, Sternberk Hospital, Czech Republic.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Nov;150(2):235-7. doi: 10.5507/bp.2006.033.
BACKGROUND
N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist.
AIM
Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer.
METHODS
Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine.
RESULTS
Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown.
CONCLUSIONS
Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.
背景
N1,N12 - 二乙酰精胺是一种最近在尿液中被鉴定出的二乙酰多胺，似乎是多种癌症的有用肿瘤标志物。目前尚无关于膀胱癌患者尿液中二乙酰精胺浓度的有效数据。
目的
评估膀胱癌患者尿液中N1,N12 - 二乙酰精胺的浓度。
方法
使用了36例膀胱尿路上皮肿瘤患者和30例良性泌尿系统疾病患者的尿液样本。在膀胱镜检查前收集尿液。对尿液中的二乙酰精胺进行酶联免疫吸附测定（ELISA）。
结果
膀胱癌患者尿液中的二乙酰精胺与对照组无差异（中位数分别为171.5和143.8，p = 0.64）。未显示其对膀胱癌检测的有效性。
结论
尿液N1,N12 - 二乙酰精胺可能不是膀胱癌的有用标志物。
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