Sugimoto M, Hiramatsu K, Kamei S, Kinoshita K, Hoshino M, Iwasaki K, Kawakita M
Self Defense Force Central Hospital, Tokyo, Japan.
J Cancer Res Clin Oncol. 1995;121(5):317-9. doi: 10.1007/BF01209602.
N1,N8-Diacetylspermidine (Ac2Spd) and N1,N12 diacetylspermine (Ac2Spm), the occurrence of which in healthy human urine was demonstrated recently, increased much more frequently and markedly than total polyamines, acetylputrescine, N1-acetylspermidine and N8-acetylspermidine in patients with urogenital malignancies. Ac2Spd was hardly elevated in cases of benign disease, while Ac2Spm only infrequently stayed within normal limits in patients with malignant disorders. Urine samples from more than 90% of healthy persons, but fewer than 10% of patients with malignancies, gave values within normal limits for both Ac2Spd and Ac2Spm. Simultaneous reference to these diacetylpolyamines is therefore useful in distinguishing patients with malignancies from healthy persons.
N1,N8 - 二乙酰亚精胺（Ac2Spd）和N1,N12 - 二乙酰精胺（Ac2Spm），最近已证实在健康人尿液中存在，在泌尿生殖系统恶性肿瘤患者中，它们的出现频率和增加程度比总多胺、乙酰腐胺、N1 - 乙酰亚精胺和N8 - 乙酰亚精胺更为频繁和显著。在良性疾病病例中，Ac2Spd几乎没有升高，而在恶性疾病患者中，Ac2Spm仅有很少情况保持在正常范围内。超过90%的健康人的尿液样本中Ac2Spd和Ac2Spm的值在正常范围内，但恶性肿瘤患者中该比例不到10%。因此，同时参考这些二乙酰多胺有助于区分恶性肿瘤患者和健康人。
