Division of Laboratory Diagnosis, Sapporo Medical University Hospital, Japan.
Clin Chim Acta. 2010 Dec 14;411(23-24):1894-9. doi: 10.1016/j.cca.2010.07.018. Epub 2010 Jul 23.
Among natural polyamines, the concentrations of the diacetylated form of spermine and spermidine increase in the urine of patients with cancer. We evaluated the utility of urinary N(1),N(12)-diacetylspermine (DiAcSpm) and N(1),N(8)-diacetylspermidine (DiAcSpd) as tumor markers for breast and colorectal cancers.
Urinary DiAcSpm and DiAcSpd concentrations were measured by an enzyme-linked immunosorbent assay. Urine and serum samples were collected from 33 and 28 patients with colorectal and breast cancers, respectively. The sensitivity of urine samples to DiAcSpm and DiAcSpd concentrations was compared with serum concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen CA 15-3 in breast cancer patients and with serum concentrations of CEA and CA 19-9 in colorectal cancer patients, respectively.
In breast cancer patients, the sensitivity of DiAcSpm and DiAcSpd was 46.4% and 14.2%, respectively, which was higher than that of CEA and CA 15-3. In patients with colorectal cancer, the sensitivity of DiAcSpm and DiAcSpd was 69.6% and 36.3%, respectively. CEA was the second sensitive marker and CA 19-9 was the least sensitive marker in these patients.
DiAcSpm is a highly sensitive tumor marker. DiAcSpm can serve as a powerful tool in settings such as initial screening for cancers in routine health examination.
在天然多胺中，精脒和亚精胺的二乙酰化形式的浓度在癌症患者的尿液中增加。我们评估了尿 N(1),N(12)-二乙酰精脒 (DiAcSpm) 和 N(1),N(8)-二乙酰亚精胺 (DiAcSpd) 作为乳腺癌和结直肠癌肿瘤标志物的效用。
通过酶联免疫吸附试验测量尿 DiAcSpm 和 DiAcSpd 浓度。从分别患有结直肠癌和乳腺癌的 33 名和 28 名患者中收集尿液和血清样本。将尿样对 DiAcSpm 和 DiAcSpd 浓度的敏感性与乳腺癌患者血清癌胚抗原 (CEA) 和碳水化合物抗原 CA 15-3 浓度以及结直肠癌患者血清 CEA 和 CA 19-9 浓度进行比较。
在乳腺癌患者中，DiAcSpm 和 DiAcSpd 的敏感性分别为 46.4%和 14.2%，高于 CEA 和 CA 15-3。在结直肠癌患者中，DiAcSpm 和 DiAcSpd 的敏感性分别为 69.6%和 36.3%。CEA 是这些患者中第二敏感的标志物，CA 19-9 是最不敏感的标志物。
DiAcSpm 是一种高度敏感的肿瘤标志物。DiAcSpm 可以作为常规健康检查中癌症初始筛查等情况下的有力工具。
