白细胞介素-4（-590 C/T）基因多态性与欧洲人口腔鳞状细胞癌风险增加密切相关。
Strong association of interleukin-4 (-590 C/T) polymorphism with increased risk for oral squamous cell carcinoma in Europeans.
作者信息
Vairaktaris Eleftherios, Yannopoulos Athanasios, Vassiliou Stavros, Serefoglou Zoe, Vylliotis Antonis, Nkenke Emeka, Critselis Elena, Avgoustidis Dimitrios, Yapijakis Christos, Neukam Friedrich W, Patsouris Efstratios
机构信息
Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Dec;104(6):796-802. doi: 10.1016/j.tripleo.2006.12.029. Epub 2007 Apr 11.
OBJECTIVE
The present study was performed to investigate the possible association of -590 C/T polymorphism in the interleukin-4 (IL-4) gene which affects its expression with the risk for development of oral cancer.
STUDY DESIGN
Polymerase chain reaction-based restriction analysis was performed in DNA samples of 156 patients with oral squamous cell carcinoma (OSCC) and 162 healthy control subjects of equivalent gender, age, and ethnicity (Greek and German). Statistical analyses were performed conducting Fisher exact test.
RESULTS
The T/T genotype was associated with an increased risk for the development of OSCC (P = .018; OR 1.47, 95% CI 0.66-3.28), especially for early stages of this malignancy (P < .0001; OR 3.17, 95% CI 1.31-7.65).
CONCLUSIONS
The above findings are consistent with the growth-promoting role of IL-4 in head and neck cancer and its inhibitory effect on neoangiogenesis and metastasis. The present study in Europeans is not in accordance with a previous report of unclear association of this polymorphism in a Chinese population.
目的
本研究旨在调查白细胞介素-4（IL-4）基因中影响其表达的-590 C/T多态性与口腔癌发生风险之间的可能关联。
研究设计
对156例口腔鳞状细胞癌（OSCC）患者和162例年龄、性别、种族（希腊人和德国人）匹配的健康对照者的DNA样本进行基于聚合酶链反应的限制性分析。采用Fisher精确检验进行统计分析。
结果
T/T基因型与OSCC发生风险增加相关（P = 0.018；比值比1.47，95%可信区间0.66 - 3.28），尤其是在该恶性肿瘤的早期阶段（P < 0.0001；比值比3.17，95%可信区间1.31 - 7.65）。
结论
上述发现与IL-4在头颈部癌中的促生长作用及其对新生血管生成和转移的抑制作用一致。本研究在欧洲人群中的结果与先前关于该多态性在中国人群中关联不明确的报告不一致。
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