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A novel borna disease virus vector system that stably expresses foreign proteins from an intercistronic noncoding region.一种新型的博尔纳病病毒载体系统，可从顺式作用非编码区稳定表达外源蛋白。
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The X protein of borna disease virus serves essential functions in the viral multiplication cycle.博尔纳病病毒的X蛋白在病毒增殖周期中发挥着重要作用。
J Virol. 2007 Jul;81(13):7297-9. doi: 10.1128/JVI.02468-06. Epub 2007 Apr 11.

本文引用的文献

1
The X protein of borna disease virus serves essential functions in the viral multiplication cycle.博尔纳病病毒的X蛋白在病毒增殖周期中发挥着重要作用。
J Virol. 2007 Jul;81(13):7297-9. doi: 10.1128/JVI.02468-06. Epub 2007 Apr 11.
2
Reverse-genetic approaches to the study of Borna disease virus.用于研究博尔纳病病毒的反向遗传学方法。
Nat Rev Microbiol. 2006 Oct;4(10):777-83. doi: 10.1038/nrmicro1489. Epub 2006 Sep 11.
3
RNA polymerase II-controlled expression of antigenomic RNA enhances the rescue efficacies of two different members of the Mononegavirales independently of the site of viral genome replication.RNA聚合酶II控制的反基因组RNA表达可增强单股负链RNA病毒目两个不同成员的拯救效率，且与病毒基因组复制位点无关。
J Virol. 2006 Jun;80(12):5708-15. doi: 10.1128/JVI.02389-05.
4
Novel insights into the regulation of the viral polymerase complex of neurotropic Borna disease virus.对嗜神经性博尔纳病病毒病毒聚合酶复合物调控的新见解。
Virus Res. 2005 Aug;111(2):148-60. doi: 10.1016/j.virusres.2005.04.006.
5
Genome trimming: a unique strategy for replication control employed by Borna disease virus.基因组修剪：博尔纳病病毒用于复制控制的独特策略。
Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3441-6. doi: 10.1073/pnas.0405965102. Epub 2005 Feb 22.
6
Rat model of borna disease virus transmission: epidemiological implications.博尔纳病病毒传播的大鼠模型：流行病学意义
J Virol. 2003 Dec;77(23):12886-90. doi: 10.1128/jvi.77.23.12886-12890.2003.
7
A reverse genetics system for Borna disease virus.博尔纳病病毒的反向遗传学系统。
J Gen Virol. 2003 Nov;84(Pt 11):3099-3104. doi: 10.1099/vir.0.19467-0.
8
Active borna disease virus polymerase complex requires a distinct nucleoprotein-to-phosphoprotein ratio but no viral X protein.活性博尔纳病病毒聚合酶复合体需要特定的核蛋白与磷蛋白比例，但不需要病毒X蛋白。
J Virol. 2003 Nov;77(21):11781-9. doi: 10.1128/jvi.77.21.11781-11789.2003.
9
Selective virus resistance conferred by expression of Borna disease virus nucleocapsid components.由博尔纳病病毒核衣壳成分表达赋予的选择性病毒抗性。
J Virol. 2003 Apr;77(7):4283-90. doi: 10.1128/jvi.77.7.4283-4290.2003.
10
Bornavirus and the brain.博尔纳病毒与大脑
J Infect Dis. 2002 Dec 1;186 Suppl 2:S241-7. doi: 10.1086/344936.

一种用于在啮齿动物神经元中表达外源基因的博尔纳病病毒载体。

A Borna disease virus vector for expression of foreign genes in neurons of rodents.

作者信息

Schneider Urs, Ackermann Andreas, Staeheli Peter

机构信息

Department of Virology, University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany.

出版信息

J Virol. 2007 Jul;81(13):7293-6. doi: 10.1128/JVI.02467-06. Epub 2007 Apr 11.

DOI:10.1128/JVI.02467-06
PMID:17428876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1933307/
Abstract

An expression cassette for green fluorescent protein was successfully inserted at a site near the 5' end of the genome of Borna disease virus (BDV). When introduced into a mutant virus with highly active polymerase, the foreign gene was strongly expressed in neurons of infected rats. Since BDV can establish long-term persistence in the central nervous system of rodents, it may be used to engineer efficient vectors for specific delivery of foreign genes into highly differentiated neurons.

摘要

绿色荧光蛋白表达盒成功插入到博尔纳病病毒（BDV）基因组5'端附近的一个位点。当将其导入具有高活性聚合酶的突变病毒中时，外源基因在受感染大鼠的神经元中强烈表达。由于BDV可在啮齿动物的中枢神经系统中长期持续存在，它可能被用于构建高效载体，以便将外源基因特异性递送至高度分化的神经元。