Jensen J H, Larsen S B
University Department of Otolaryngology, Hvidovre Hospital, Denmark.
Clin Otolaryngol Allied Sci. 1991 Oct;16(5):498-500. doi: 10.1111/j.1365-2273.1991.tb01048.x.
The failure of treatment with penicillin in patients suffering from acute beta-haemolytic streptococcus Group A tonsillitis, may be due to the presence of beta-lactamase-producing bacteria. Several studies indicate that treatment with clindamycin may prevent recurrence and thereby eliminate the need for tonsillectomy. In this prospective study, 54 patients with recurrent acute tonsillitis were investigated. 29 patients were treated with clindamycin, 150 mg 4 times daily for 10 days, while 25 patients received no antibiotic treatment and served as a control group. A significantly reduced number of episodes of acute tonsillitis (P less than 0.01) and of tonsillectomy (P less than 0.001) was found in the group of patients treated with clindamycin.
患有急性A组β溶血性链球菌扁桃体炎的患者使用青霉素治疗失败，可能是由于存在产β-内酰胺酶的细菌。多项研究表明，使用克林霉素治疗可预防复发，从而避免扁桃体切除术。在这项前瞻性研究中，对54例复发性急性扁桃体炎患者进行了调查。29例患者接受克林霉素治疗，每日4次，每次150mg，共10天，而25例患者未接受抗生素治疗，作为对照组。在接受克林霉素治疗的患者组中，急性扁桃体炎发作次数（P<0.01）和扁桃体切除术数量（P<0.001）均显著减少。
