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青光眼患者视网膜神经纤维厚度与行为敏感性的关系:线性模型的应用

Relating retinal nerve fiber thickness to behavioral sensitivity in patients with glaucoma: application of a linear model.

作者信息

Hood Donald C

机构信息

Department of Psychology, Columbia University, New York, NY 10027, USA.

出版信息

J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1426-30. doi: 10.1364/josaa.24.001426.

DOI:10.1364/josaa.24.001426
PMID:17429489
Abstract

Glaucoma causes damage to the retinal ganglion cells and their axons, and this damage can be detected with both structural and functional tests. The purpose of this study was to better understand the relationship between a structural measure of retinal nerve fiber layer (RNFL) and the most common functional test, behavioral sensitivity with static automated perimetry (SAP). First, a linear model, previously shown to describe the relationship between local visual evoked potentials and SAP sensitivity, was modified to predict the change in RNFL as measured by optical coherence tomography. Second, previous work by others was shown to be consistent with this model.

摘要

青光眼会损害视网膜神经节细胞及其轴突,这种损害可以通过结构和功能测试检测出来。本研究的目的是更好地理解视网膜神经纤维层(RNFL)的结构测量与最常见的功能测试——静态自动视野计(SAP)的行为敏感度之间的关系。首先,修改了一个先前已被证明可描述局部视觉诱发电位与SAP敏感度之间关系的线性模型,以预测光学相干断层扫描测量的RNFL变化。其次,其他人之前的研究结果与该模型一致。

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