胰岛素降解酶编码基因定位于人类第10号染色体q23----q25带。
Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25.
作者信息
Espinosa R, Lemons R S, Perlman R K, Kuo W L, Rosner M R, Le Beau M M
机构信息
Department of Medicine, University of Chicago, IL.
出版信息
Cytogenet Cell Genet. 1991;57(4):184-6. doi: 10.1159/000133142.
Insulin-degrading enzyme (IDE) is a cytosolic proteinase involved in the cellular processing of insulin. Using somatic cell hybrid analysis and in situ chromosomal hybridization, we have localized the gene encoding IDE to human chromosome 10, bands q23----q25. The murine Ide gene was previously mapped to Chromosome 19; together, these results suggest that the IDE gene is a member of a conserved syntenic group on human chromosome 10, bands q23----q25 and mouse Chromosome 19.
胰岛素降解酶（IDE）是一种参与胰岛素细胞加工过程的胞质蛋白酶。通过体细胞杂交分析和原位染色体杂交，我们已将编码IDE的基因定位于人类10号染色体q23至q25带。小鼠Ide基因先前被定位于19号染色体；这些结果共同表明，IDE基因是人类10号染色体q23至q25带和小鼠19号染色体上保守同线群的成员。
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