Aksoy Hulya, Aksoy Ayse Nur, Ozkan Asuman, Polat Harun
Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey.
J Clin Lab Anal. 2009;23(2):105-9. doi: 10.1002/jcla.20298.
The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty-six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoproteins A1 (apo A1) and B (apo B), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL-C, and apo B levels were not different among; the groups (P>0.05), HDL-C (P=0.01) and apo A1 (P=0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 (P=0.03) and arylesterase activities (P=0.03) compared with the control group. Additionally, mean TAO values were lower (P=0.01) and MDA levels were higher (P=0.02) in HG group than in the healthy pregnants. A significant negative correlation between PON1 and MDA was found in HG group (r=-0.33, P<0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired.
本研究的目的是调查妊娠剧吐（HG）患者血清中的血脂谱、对氧磷酶1（PON1）活性和氧化应激状态。该研究纳入了36例HG病例和36例正常孕妇。测定了血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（apo A1）和B（apo B）、丙二醛（MDA）以及总抗氧化活性（TAO）值，以及PON1和芳基酯酶活性。虽然各组之间血清TC、TG、LDL-C和apo B水平无差异（P>0.05），但HG患者的HDL-C（P=0.01）和apo A1（P=0.007）水平低于正常孕妇。与对照组相比，HG组的血清PON1（P=0.03）和芳基酯酶活性（P=0.03）显著降低。此外，HG组的平均TAO值较低（P=0.01），MDA水平较高（P=0.02）。HG组中PON1与MDA之间存在显著负相关（r=-0.33，P<0.05）。本研究结果表明，HG可能是氧化与抗氧化平衡受损的情况之一。
