Kang Jae Hee, Grodstein Francine
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Neurobiol Aging. 2008 Sep;29(9):1394-403. doi: 10.1016/j.neurobiolaging.2007.03.006. Epub 2007 Apr 11.
As a site of high metabolic activity, the brain is particularly susceptible to oxidative damage. We explored the association between plasma antioxidants and cognition. In 858 female participants of the Nurses' Health Study, aged 70+ years, we measured plasma carotenoids and tocopherols in 1989-1990, and assessed cognitive function by telephone beginning in 1995-2001; assessments were repeated twice at 2-year intervals. We used linear regression to estimate multivariable-adjusted mean cognitive performance at the initial assessment by quartile of antioxidants, and longitudinal models for analyzing cognitive decline over 4 years. Higher antioxidant levels were not associated with initial performance or decline. Mean difference in initial global composite score (averaging all six cognitive tests) for the top versus bottom quartile of total carotenoids was -0.05 standard units (95% confidence interval [CI] -0.19, 0.09), and 0.04 units for total tocopherols (95% CI -0.10, 0.18). Individual antioxidants were not associated with cognition. Overall, total plasma carotenoids or tocopherols were not related to cognition in women.
作为高代谢活动的场所，大脑特别容易受到氧化损伤。我们探讨了血浆抗氧化剂与认知之间的关联。在护士健康研究中的858名70岁及以上的女性参与者中，我们于1989 - 1990年测量了她们血浆中的类胡萝卜素和生育酚，并从1995 - 2001年开始通过电话评估认知功能；评估每两年重复进行两次。我们使用线性回归按抗氧化剂四分位数估计初次评估时多变量调整后的平均认知表现，并使用纵向模型分析4年中的认知衰退情况。较高的抗氧化剂水平与初始表现或衰退无关。总类胡萝卜素最高四分位数与最低四分位数相比，初次总体综合评分（对所有六项认知测试进行平均）的平均差异为 - 0.05标准单位（95%置信区间[CI] - 0.19, 0.09），总生育酚为0.04单位（95% CI - 0.10, 0.18）。单个抗氧化剂与认知无关。总体而言，女性血浆中的总类胡萝卜素或生育酚与认知无关。
