抗氧化剂、锌和铜对老年人认知功能的影响：一项随机对照试验。
Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.
作者信息
Yaffe Kristine, Clemons Traci E, McBee Wendy L, Lindblad Anne S
机构信息
Department of Psychiatry, University of California, San Francisco, and San Francisco VA Medical Center, CA, USA.
出版信息
Neurology. 2004 Nov 9;63(9):1705-7. doi: 10.1212/01.wnl.0000142969.19465.8f.
Abstract
Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.
摘要
年龄相关性眼病研究的参与者被随机分配接受每日抗氧化剂（维生素C，500毫克；维生素E，400国际单位；β-胡萝卜素，15毫克）、锌和铜（锌，80毫克；氧化铜，2毫克）、抗氧化剂加锌和铜或安慰剂。在治疗中位数6.9年后，对2166名老年人进行了一组认知测试。在六项认知测试中的任何一项上，治疗组之间均无差异（所有p>0.05）。这些结果不支持抗氧化剂或锌和铜对老年人认知有有益或有害影响的观点。
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