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Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements: the Cache County Study.抗氧化维生素补充剂使用者患阿尔茨海默病的风险降低：卡什县研究
Arch Neurol. 2004 Jan;61(1):82-8. doi: 10.1001/archneur.61.1.82.
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Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study.在一项双种族社区研究中抗氧化营养素的膳食摄入量与阿尔茨海默病发病风险
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A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.一项关于高剂量补充维生素C、维生素E、β-胡萝卜素和锌对年龄相关性黄斑变性及视力丧失影响的随机、安慰剂对照临床试验：年龄相关性眼病研究组报告第8号。
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Rapid induction of Alzheimer A beta amyloid formation by zinc.锌快速诱导阿尔茨海默病β淀粉样蛋白形成。
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抗氧化剂、锌和铜对老年人认知功能的影响：一项随机对照试验。

Impact of antioxidants, zinc, and copper on cognition in the elderly: a randomized, controlled trial.

作者信息

Yaffe Kristine, Clemons Traci E, McBee Wendy L, Lindblad Anne S

机构信息

Department of Psychiatry, University of California, San Francisco, and San Francisco VA Medical Center, CA, USA.

出版信息

Neurology. 2004 Nov 9;63(9):1705-7. doi: 10.1212/01.wnl.0000142969.19465.8f.

DOI:10.1212/01.wnl.0000142969.19465.8f
PMID:15534261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1473037/
Abstract

Participants in the Age-Related Eye Disease Study were randomly assigned to receive daily antioxidants (vitamin C, 500 mg; vitamin E, 400 IU; beta carotene, 15 mg), zinc and copper (zinc, 80 mg; cupric oxide, 2 mg), antioxidants plus zinc and copper, or placebo. A cognitive battery was administered to 2,166 elderly persons after a median of 6.9 years of treatment. Treatment groups did not differ on any of the six cognitive tests (p > 0.05 for all). These results do not support a beneficial or harmful effect of antioxidants or zinc and copper on cognition in older adults.

摘要

年龄相关性眼病研究的参与者被随机分配接受每日抗氧化剂（维生素C，500毫克；维生素E，400国际单位；β-胡萝卜素，15毫克）、锌和铜（锌，80毫克；氧化铜，2毫克）、抗氧化剂加锌和铜或安慰剂。在治疗中位数6.9年后，对2166名老年人进行了一组认知测试。在六项认知测试中的任何一项上，治疗组之间均无差异（所有p>0.05）。这些结果不支持抗氧化剂或锌和铜对老年人认知有有益或有害影响的观点。