Lightman S
Moorfields Eye Hospital, London.
Eye (Lond). 1991;5 ( Pt 4):432-7. doi: 10.1038/eye.1991.69.
Posterior segment inflammatory disease can have several different effects on the retinal vasculature, all of which have potentially sight threatening consequences. Blood-retinal barrier breakdown is a common feature of the disease process with resulting retinal and macula oedema. Very little is known about the mechanism of this breakdown and in particular whether it is at the endothelial cell membrane or at the tight junctions between the endothelial cells--a matter of importance if better therapeutic regimes are to be devised in the future. This paper looks at this question in two animal models of posterior uveitis using different techniques.
后段炎症性疾病可对视网膜血管系统产生多种不同影响，所有这些影响都可能导致视力威胁。血视网膜屏障破坏是疾病过程中的一个常见特征，会导致视网膜和黄斑水肿。对于这种破坏的机制知之甚少，尤其是它是发生在内皮细胞膜还是内皮细胞之间的紧密连接处——如果未来要设计出更好的治疗方案，这是一个重要问题。本文使用不同技术在两种后葡萄膜炎动物模型中研究了这个问题。
