Atkinson E G, Jones S, Ellis B A, Dumonde D C, Graham E
Department of Immunology, United Medical School, London.
Eye (Lond). 1991;5 ( Pt 4):440-6. doi: 10.1038/eye.1991.71.
In order to investigate the selective breakdown of the blood-retinal barrier in posterior uveitis angiograms were performed using fluorescein-conjugated dextrans (FITC-dextrans) of different molecular weights (150-kDa, 20-kDa, and 4-kDa) in two healthy controls and six patients with posterior uveitis, and the results compared with those of conventional fluorescein angiography. The smallest FITC-dextran could not penetrate the healthy blood-retinal barrier. Leakage of FITC-dextrans of all sizes was seen from swollen optic discs; dextrans of 4-kDa and 20-kDa leaked from areas of macula oedema; and retinal new vessels allowed the passage of 4-kDa molecules only. These results indicate that there is a differential breakdown of the blood-retinal barrier according to molecular size in various clinical situations associated with posterior uveitis.
为了研究后葡萄膜炎中血视网膜屏障的选择性破坏情况，我们使用不同分子量（150 kDa、20 kDa和4 kDa）的荧光素偶联葡聚糖（FITC-葡聚糖）对两名健康对照者和六名后葡萄膜炎患者进行了血管造影，并将结果与传统荧光素血管造影的结果进行了比较。最小的FITC-葡聚糖无法穿透健康的血视网膜屏障。在肿胀的视盘处可见各种大小的FITC-葡聚糖渗漏；4 kDa和20 kDa的葡聚糖从黄斑水肿区域渗漏；而视网膜新生血管仅允许4 kDa分子通过。这些结果表明，在与后葡萄膜炎相关的各种临床情况下，血视网膜屏障会根据分子大小发生不同程度的破坏。
