Ligtenberg Antoon J M, de Soet Johannes J, Veerman Enno C I, Amerongen Arie V Nieuw
Department of Oral Biochemistry, Academic Centre for Dentistry, Amsterdam, the Netherlands.
Ann N Y Acad Sci. 2007 Mar;1098:200-3. doi: 10.1196/annals.1384.040.
In addition to saliva, other oral components such as gingival crevicular fluid, epithelial cells, bacteria, breath, and dental plaque have diagnostic potential. For oral diseases such as caries and periodontal disease, visual diagnosis is usually adequate, but objective diagnostic tests with predictive value are desired. Therefore, prediction models like the Cariogram have been developed that also include oral aspects such as saliva secretion, buffering capacity, and Streptococcus mutans counts for the prediction of caries. Correlation studies on salivary components and caries have not been conclusive, but correlation studies on functional aspects, such as saliva-induced bacterial aggregation and caries, look promising. Modern proteomic techniques make it possible to study simultaneously the many salivary components involved in these functions.
除了唾液外，其他口腔成分，如龈沟液、上皮细胞、细菌、口气和牙菌斑也具有诊断潜力。对于龋齿和牙周病等口腔疾病，通常通过视觉诊断就足够了，但仍需要具有预测价值的客观诊断测试。因此，已经开发出了如龋病风险预测模型（Cariogram）等预测模型，该模型还纳入了唾液分泌、缓冲能力和变形链球菌计数等口腔因素来预测龋齿。关于唾液成分与龋齿的相关性研究尚无定论，但关于功能方面的相关性研究，如唾液诱导的细菌聚集与龋齿的关系，前景看好。现代蛋白质组学技术使同时研究参与这些功能的众多唾液成分成为可能。
