Bhattacharya Samir, Dey Debleena, Roy Sib Sankar
Cellular and Molecular Endocrinology Laboratory, Department of Zoology, School of Life Science, Visva-Bharati (A Central University), Santiniketan 731 235, India.
J Biosci. 2007 Mar;32(2):405-13. doi: 10.1007/s12038-007-0038-8.
Free fatty acids are known to play a key role in promoting loss of insulin sensitivity,thereby causing insulin resistance and type 2 diabetes.However,the underlying mechanism involved is still unclear.In searching for the cause of the mechanism,it has been found that palmitate inhibits insulin receptor (IR)gene expression,leading to a reduced amount of IR protein in insulin target cells. PDK1-independent phosphorylation of PKC(eta) causes this reduction in insulin receptor gene expression.One of the pathways through which fatty acid can induce insulin resistance in insulin target cells is suggested by these studies.We provide an overview of this important area,emphasizing the current status.
众所周知，游离脂肪酸在促进胰岛素敏感性丧失方面起着关键作用，从而导致胰岛素抵抗和2型糖尿病。然而，其中涉及的潜在机制仍不清楚。在寻找该机制的原因时，发现棕榈酸酯抑制胰岛素受体（IR）基因表达，导致胰岛素靶细胞中IR蛋白数量减少。PKC（η）的不依赖PDK1的磷酸化导致胰岛素受体基因表达的这种减少。这些研究提示了脂肪酸可在胰岛素靶细胞中诱导胰岛素抵抗的一种途径。我们概述了这一重要领域，并强调了当前的研究现状。
