Reulbach Udo, Bleich Stefan, Biermann Teresa, Pfahlberg Annette, Sperling Wolfgang
Department of Psychiatry and Psychotherapy, Friedich-Alexander University of Erlangen-Nuremberg, Nuremberg, Germany.
J Nerv Ment Dis. 2007 Apr;195(4):315-9. doi: 10.1097/01.nmd.0000261878.55882.55.
According to the stress diathesis model, the probability of psychosis is increased in high-risk groups, a vulnerable one being the Holocaust child survivors. This study was conducted to inquire into the long-term effects of their Holocaust experience. We concentrated on a possible association between the onset of schizophrenia and the degree of persecution. Ninety-three medical files of Holocaust child survivors were recruited from sociomedical expert reports of the Restitution Office in Germany. The onset of schizophrenia was used as dependent variable in a categorical regression model. Regarding schizophrenia, exclusively late-onset schizophrenia could be diagnosed in our sample. Schizophrenia was significantly associated with the highest category of persecution (Fisher exact test, p < 0.001). In the categorical regression model, the category of persecution was a significant coefficient, only (F = 23.9, p < 0.001). The strong association between late onset of schizophrenia and the degree of persecution suggest an influence of stress exposure.
根据应激素质模型，高危人群患精神病的概率会增加，大屠杀儿童幸存者就是易患人群之一。本研究旨在探究他们的大屠杀经历所产生的长期影响。我们重点关注精神分裂症的发病与迫害程度之间可能存在的关联。从德国赔偿办公室的社会医学专家报告中收集了93份大屠杀儿童幸存者的医疗档案。在一个分类回归模型中，将精神分裂症的发病作为因变量。关于精神分裂症，在我们的样本中仅能诊断出晚发性精神分裂症。精神分裂症与最高等级的迫害显著相关（费舍尔精确检验，p < 0.001）。在分类回归模型中，迫害等级是一个显著系数，仅此而已（F = 23.9，p < 0.001）。精神分裂症的晚发与迫害程度之间的强烈关联表明应激暴露存在影响。
