Seedat Soraya, Fritelli Vega, Oosthuizen Piet, Emsley Robin A, Stein Dan J
Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
J Nerv Ment Dis. 2007 Apr;195(4):320-4. doi: 10.1097/01.nmd.0000253782.47140.ac.
This study describes the prevalence and distribution of anxiety symptomatology and anxiety disorders in a sample of hospitalized patients with schizophrenia, the estimated level of agreement between a clinician diagnostic measure and anxiety symptom status measures, and their internal consistency based on the average interitem correlations. Seventy inpatients receiving treatment for schizophrenia were assessed before discharge using a face-to-face diagnostic interview and structured questionnaires, namely the Mini International Neuropsychiatric Interview, the Hospital Anxiety and Depression Scale, the Hamilton Anxiety Scale, the Spielberger Anxiety Inventory, and the Stein Generalized Anxiety Disorder (GAD) Scale. About a quarter of patients met criteria for an anxiety disorder, with GAD and social phobia occurring most commonly. There was poor agreement between the Mini International Neuropsychiatric Interview and a diagnosis of anxiety based on symptom status measures. The Stein GAD scale demonstrated the highest internal consistency (0.85) followed by the Hamilton Anxiety Scale (0.76). Anxiety disorders and anxiety symptomatology are highly prevalent in schizophrenia. Accurate assessment is challenging yet important. More reliable measures of anxiety disorders in patients with schizophrenia and other psychotic disorders are clearly needed to allow for timely identification and treatment.
本研究描述了住院精神分裂症患者样本中焦虑症状和焦虑症的患病率及分布情况，临床诊断措施与焦虑症状状态测量之间的估计一致性水平，以及基于平均项目间相关性的内部一致性。使用面对面诊断访谈和结构化问卷，即《迷你国际神经精神病学访谈》、《医院焦虑抑郁量表》、《汉密尔顿焦虑量表》、《斯皮尔伯格焦虑量表》和《斯坦广泛性焦虑障碍量表》，对70名接受精神分裂症治疗的住院患者在出院前进行了评估。约四分之一的患者符合焦虑症标准，其中广泛性焦虑障碍和社交恐惧症最为常见。《迷你国际神经精神病学访谈》与基于症状状态测量的焦虑症诊断之间的一致性较差。斯坦广泛性焦虑障碍量表显示出最高的内部一致性（0.85），其次是汉密尔顿焦虑量表（0.76）。焦虑症和焦虑症状在精神分裂症中非常普遍。准确评估具有挑战性但很重要。显然需要更可靠的精神分裂症和其他精神障碍患者焦虑症测量方法，以便及时识别和治疗。
