Hansen A M, Poulsen O M, Christensen J M
Danish National Institute of Occupational Health, Copenhagen.
Int Arch Occup Environ Health. 1991;63(4):247-52. doi: 10.1007/BF00386373.
In the present study, data on the concentration of polycyclic aromatic hydrocarbons (PAH) in air samples from fish smokehouses (Nordholm et al. 1986) and meat smokehouses (Hansen et al. submitted for publication) were used to analyze the extent to which six different volatile PAH compounds could function as markers for the total concentration of six different carcinogenic particulate PAH compounds. Although a significant positive correlation was observed between the concentration of each of six volatile compounds and the total concentration of carcinogenic PAH compounds, a particularly good correlation was observed for phenanthrene, anthracene, fluoranthene and pyrene. Calculations of the sensitivity, specificity, positive predictive value and negative predictive value of these potential markers revealed that naphthalene and phenanthrene exhibited the highest sensitivity as markers for total carcinogenic PAH compounds in air samples from smokehouses, whereas fluoranthene and pyrene displayed the highest specificity. However, when the applicability of the six markers was tested on air samples from iron foundries, only naphthalene and pyrene were useful as markers for the carcinogenic compounds. The present study indicates that naphthalene and pyrene might function as markers for carcinogenic PAH compounds, that are present at low concentrations and are therefore difficult and time-consuming to measure directly.
在本研究中，来自鱼类烟熏房（Nordholm等人，1986年）和肉类烟熏房（Hansen等人，待发表）的空气样本中多环芳烃（PAH）浓度的数据，被用于分析六种不同挥发性PAH化合物能够在多大程度上作为六种不同致癌性颗粒状PAH化合物总浓度的标志物。尽管在六种挥发性化合物各自的浓度与致癌性PAH化合物的总浓度之间观察到显著的正相关，但菲、蒽、荧蒽和芘的相关性尤为良好。对这些潜在标志物的敏感性、特异性、阳性预测值和阴性预测值的计算表明，萘和菲作为烟熏房空气样本中总致癌性PAH化合物的标志物表现出最高的敏感性，而荧蒽和芘则显示出最高的特异性。然而，当在铸铁厂的空气样本上测试这六种标志物的适用性时，只有萘和芘可作为致癌化合物的标志物。本研究表明，萘和芘可能作为致癌性PAH化合物的标志物，这些化合物浓度较低，因此直接测量既困难又耗时。
