Thomsen H S, Golman K, Larsen S, Hemmingsen L, Skaarup P
Department of Diagnostic Radiology, Herlev Hospital, University of Copenhagen, Denmark.
Invest Radiol. 1991 Nov;26(11):951-9. doi: 10.1097/00004424-199111000-00006.
Urine chemical profiles were followed for three or nine days after intravenous injection of diatrizoate, iohexol, or saline in 30 rats, where a tubulointerstitial nephropathy was induced by gentamicin given over an eight-day period. Another ten rats injected with saline served as controls. Compared to injection of saline, both iohexol and diatrizoate induced dysfunction. The excretion of the cytoplasmic enzyme lactate dehydrogenase was significantly greater following iohexol than following diatrizoate. No significant differences between the two media were shown by the various serum components examined. Among the gentamicin-treated rats, light microscopy showed prolonged occurrence of tubular necrosis and a more intensive round cell infiltration following iohexol than following diatrizoate and saline. Both contrast media induced further temporary renal dysfunction in rats with gentamicin nephropathy; iohexol induced more morphologic changes than diatrizoate.
对30只大鼠静脉注射泛影葡胺、碘海醇或生理盐水后，连续三天或九天跟踪其尿液化学指标。这30只大鼠在八天内注射庆大霉素诱发了肾小管间质性肾病。另外十只注射生理盐水的大鼠作为对照。与注射生理盐水相比，碘海醇和泛影葡胺均诱发了功能障碍。碘海醇注射后细胞质酶乳酸脱氢酶的排泄量显著高于泛影葡胺注射后。所检测的各种血清成分在两种造影剂之间未显示出显著差异。在庆大霉素处理的大鼠中，光学显微镜检查显示，碘海醇注射后肾小管坏死持续时间延长，圆形细胞浸润比泛影葡胺和生理盐水注射后更强烈。两种造影剂均诱发庆大霉素肾病大鼠出现进一步的暂时性肾功能障碍；碘海醇诱发的形态学变化比泛影葡胺更多。
