Thomsen H S, Hemmingsen L, Golman K, Skaarup P, Larsen S
Department of Diagnostic Radiology, University of Copenhagen, Herlev, Denmark.
Acta Radiol. 1990 Nov;31(6):613-8.
Urine profiles were followed for 3 or 9 days after intravenous injection of diatrizoate, iohexol, or saline in 30 adult Wistar rats, which received a low sodium diet for 14 days, and indomethacin intravenously 2 hours and immediately before contrast medium or saline injection. A control group of 10 rats, which also received low sodium diet, got saline alone and no indomethacin or contrast medium. Diatrizoate increased albuminuria during the first 22 hours after its injection whereas iohexol did not have any significant effect on albuminuria. Both contrast media caused tubular dysfunction, but there was significant difference between them during the first 2 hours after injection. Compared to the effect of saline, iohexol but not diatrizoate caused increased excretion of lactate dehydrogenase and N-acetyl-beta-glucosaminidase for 2 days. Iodine measurements showed delayed excretion of both media. Light microscopy showed focal location of dilated tubular profiles with hydrophia, which were only present in kidneys exposed to contrast media. It is concluded that in rats fed on a low sodium diet administration of indomethacin in relation to iohexol has a greater tubular cell effect than diatrizoate, which in turn has a greater effect on the glomerular permeability. The excretion of both media is delayed.
在30只成年Wistar大鼠中，给予低钠饮食14天，并在静脉注射泛影葡胺、碘海醇或生理盐水前2小时及即将注射造影剂或生理盐水时静脉注射吲哚美辛，之后跟踪尿液指标3天或9天。10只大鼠组成的对照组同样给予低钠饮食，仅注射生理盐水，未注射吲哚美辛或造影剂。泛影葡胺在注射后的最初22小时内增加蛋白尿，而碘海醇对蛋白尿无显著影响。两种造影剂均导致肾小管功能障碍，但在注射后的最初2小时内两者存在显著差异。与生理盐水的作用相比，碘海醇而非泛影葡胺使乳酸脱氢酶和N-乙酰-β-氨基葡萄糖苷酶的排泄增加，持续2天。碘含量测定显示两种造影剂的排泄均延迟。光学显微镜检查显示扩张的肾小管轮廓呈局灶性分布且有嗜水性，仅在暴露于造影剂的肾脏中出现。得出的结论是，在低钠饮食的大鼠中，与碘海醇相关的吲哚美辛给药对肾小管细胞的影响大于泛影葡胺，而泛影葡胺对肾小球通透性的影响更大。两种造影剂的排泄均延迟。
