Thomsen H S, Skaarup P, Larsen S, Golman K, Hemmingsen L
Department of Diagnostic Radiology, University of Copenhagen, Herlev.
Acta Radiol. 1990 Jul;31(4):401-7.
Urine profiles were followed for 3 or 9 days after intravenous injection of diatrizoate, iohexol or saline in 30 rats, where a tubulo-interstitial nephropathy was induced by gentamicin given over a 14-day period. Another 10 rats who had an injection of saline served as controls. Iohexol increased the excretion of lactate dehydrogenase significantly more than both saline and diatrizoate for the first 3 days, whereas diatrizoate had no effect. Both media caused significantly increased excretion of L-gamma-glutamyltransferase compared with saline, but iohexol significantly more than diatrizoate. Compared with saline S-creatinine was significantly increased following iohexol at 24 h, 3 and 9 days, and following diatrizoate only at 9 days. Among rats having gentamicin light microscopy revealed more severe changes in kidneys exposed to iohexol than to either diatrizoate or saline 3 days after their injection. Six days later no obvious differences were found between the 3 groups. In conclusion, iohexol induced more renal dysfunction than diatrizoate in this animal model of gentamicin induced nephropathy.
在30只大鼠中，通过连续14天给予庆大霉素诱导肾小管间质性肾病，然后静脉注射泛影葡胺、碘海醇或生理盐水，之后对其尿液指标进行了3天或9天的跟踪监测。另外10只注射生理盐水的大鼠作为对照。在最初3天，碘海醇使乳酸脱氢酶的排泄量显著高于生理盐水和泛影葡胺，而泛影葡胺则无此作用。与生理盐水相比，两种造影剂均使L-γ-谷氨酰转移酶的排泄量显著增加，但碘海醇增加的幅度明显大于泛影葡胺。与生理盐水相比，注射碘海醇后24小时、3天和9天以及注射泛影葡胺后仅9天，S-肌酐显著升高。在注射后3天，在接受庆大霉素治疗的大鼠中，光镜检查显示，与接受泛影葡胺或生理盐水的大鼠相比，接受碘海醇的大鼠肾脏变化更为严重。6天后，三组之间未发现明显差异。总之，在这种庆大霉素诱导的肾病动物模型中，碘海醇比泛影葡胺诱导的肾功能障碍更严重。
