Thomsen H S, Goldman K, Svendsen O, Skaarup P, Hemmingsen L, Larsen S
Department of Diagnostic Radiology, Herlev Hospital, University of Copenhagen, Denmark.
Invest Radiol. 1991 Dec;26(12):1083-6. doi: 10.1097/00004424-199112000-00010.
The effects on urine and serum profiles of intravenous injection of diatrizoate, iohexol, or saline were studied in male rats pretreated with steroids or saline. Using urinary albumin, glucose, sodium, and the enzymes lactate dehydrogenase (LDH), gamma-glutamyltransferase (GGT), and N-acetyl-beta-D-glucosaminidase (NAG) as markers of glomerular and tubular function, it was found that diatrizoate caused temporary glomerular and tubular dysfunction; the effect was independent of the kind of pretreatment. Iohexol did not cause increased glomerular permeability in steroid- and saline-pretreated rats. When used following saline, iohexol induced increased excretion of three tubular components, whereas iohexol plus steroids caused increased excretion of all five tubular components. The dysfunctional effect of iohexol plus steroids was less than that of diatrizoate plus steroids. The serum components revealed no abnormalities induced by either contrast media or methylprednisolone. Pretreatment with steroids has no effect on the glomerular or tubular dysfunctional effect of diatrizoate, whereas it worsens the temporary tubular dysfunctional effect of iohexol in rats.
在经类固醇或生理盐水预处理的雄性大鼠中，研究了静脉注射泛影葡胺、碘海醇或生理盐水对尿液和血清指标的影响。以尿白蛋白、葡萄糖、钠以及乳酸脱氢酶（LDH）、γ-谷氨酰转移酶（GGT）和N-乙酰-β-D-氨基葡萄糖苷酶（NAG）等酶作为肾小球和肾小管功能的标志物，发现泛影葡胺会导致暂时性肾小球和肾小管功能障碍；该效应与预处理的类型无关。在经类固醇和生理盐水预处理的大鼠中，碘海醇不会导致肾小球通透性增加。在生理盐水预处理后使用时，碘海醇会导致三种肾小管成分的排泄增加，而碘海醇加类固醇会导致所有五种肾小管成分的排泄增加。碘海醇加类固醇的功能障碍效应小于泛影葡胺加类固醇。血清成分未显示出由造影剂或甲基强的松龙引起的异常。类固醇预处理对泛影葡胺的肾小球或肾小管功能障碍效应没有影响，而它会加重碘海醇在大鼠中的暂时性肾小管功能障碍效应。
