酒精对小脑性协同失调性肌阵挛中肌阵挛及体感诱发电位的影响。
Effects of alcohol on myoclonus and somatosensory evoked potentials in dyssynergia cerebellaris myoclonica.
作者信息
Lu C S, Chu N S
机构信息
Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan.
出版信息
J Neurol Neurosurg Psychiatry. 1991 Oct;54(10):905-8. doi: 10.1136/jnnp.54.10.905.
Three brothers with dyssynergia cerebellaris myoclonica received alcohol to study the correlation between improvement of myoclonus and alteration in somatosensory evoked potentials (SEPs). Alcohol considerably improved myoclonus for about six hours in two patients (cases 1 and 2) but had only a mild effect in one (case 3). All three patients had giant cortical SEPs. The amplitudes of median N20-P25 and P25-N35 components and tibial N30-P40 and P40-N50 components were considerably decreased after alcohol ingestion in two patients (cases 1 and 2) but unchanged or slightly decreased in one (case 3). The peak latencies of those components were not affected by alcohol. There was thus a good correlation between the suppression of myoclonus and the decrease in giant SEP amplitude.
三名患有肌阵挛性小脑协同失调的兄弟接受了酒精测试，以研究肌阵挛改善与体感诱发电位（SEP）变化之间的相关性。酒精使两名患者（病例1和病例2）的肌阵挛在约6小时内得到显著改善，但对另一名患者（病例3）仅有轻微作用。所有三名患者均有巨大皮质SEP。两名患者（病例1和病例2）摄入酒精后，正中神经N20 - P25和P25 - N35成分以及胫神经N30 - P40和P40 - N50成分的波幅显著降低，但另一名患者（病例3）的波幅未变或略有降低。这些成分的峰潜伏期不受酒精影响。因此，肌阵挛的抑制与巨大SEP波幅的降低之间存在良好的相关性。
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