Teklu Sisay, Gaym Asheber
Addis Ababa University, Medical Faculty, Ethiopia.
Ethiop Med J. 2006 Jan;44(1):17-26.
A one-year longitudinal study was conducted at Tikur Anbessa central referral Hospital to assess the prevalence of hypertensive disorders of pregnancy (HDP), to see the socio-demographic and clinical parameters and pregnancy outcome of pregnancies afflicted by these complications. Out of 3424 deliveries conducted during the study period, 183 (5.3%) mothers were found to have one form of hypertensive disorders of pregnancy, 85.2% were cases of pregnancy induced hypertension (PIH),the majority (78.2%) were severe pre eclampsia and eclampsia; the remaining 14.8% had pregnancy aggravated hypertension (PAH) or chronic hypertension. Preterm delivery rate was 48.6% for all cases of HDP. Intervention rate was high with 44.3% induction of labor and 44.3% caesarian section, which is much higher than the over all intervention rate in the hospital's obstetric population during the studied period. Prenatal mortality rate (PNMR), case fatality rate (CFR) and intra uterine growth restriction (IUGR) were 300/1000 deliveries, 27/1000 deliveries and 41.6% respectively in mothers with HDP. Severe hypertension, high urine protein and high uric acid level were found to be associated with higher CFR, and poor prenatal outcome. The study provides base line data on HDP in a hospital obstetric population in Ethiopia. Important peculiar findings in this study were a very high rate of severe disease, PNMR and CFR compared to other institutional studies. There is a need to conduct nation wide multi center study on HDP in order to have national base line data on this important pregnancy complication.
在提古安贝萨中央转诊医院进行了一项为期一年的纵向研究，以评估妊娠高血压疾病（HDP）的患病率，了解受这些并发症影响的妊娠的社会人口统计学和临床参数以及妊娠结局。在研究期间进行的3424例分娩中，发现183名（5.3%）母亲患有某种形式的妊娠高血压疾病，其中85.2%为妊娠高血压（PIH）病例，大多数（78.2%）为重度子痫前期和子痫；其余14.8%患有妊娠合并高血压（PAH）或慢性高血压。所有HDP病例的早产率为48.6%。干预率很高，引产率为44.3%，剖宫产率为44.3%，远高于研究期间该医院产科人群的总体干预率。HDP母亲的产前死亡率（PNMR）、病死率（CFR）和宫内生长受限（IUGR）分别为每1000例分娩300例、每1000例分娩27例和41.6%。发现重度高血压、高尿蛋白和高尿酸水平与较高的CFR及不良的产前结局相关。该研究提供了埃塞俄比亚一家医院产科人群中HDP的基线数据。本研究的重要特殊发现是，与其他机构研究相比，严重疾病、PNMR和CFR的发生率非常高。有必要就HDP开展全国范围的多中心研究，以便获得关于这一重要妊娠并发症的全国基线数据。
