中国汉族人群寻常痤疮的家族风险——一项病例对照研究
The familial risk of acne vulgaris in Chinese Hans - a case-control study.
作者信息
Xu S X, Wang H L, Fan X, Sun L D, Yang S, Wang P G, Xiao F L, Gao M, Cui Y, Ren Y Q, Du W H, Quan C, Zhang X J
机构信息
Institute of Dermatology & Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, China, and Key Laboratory of Genome Research in Hefei, Anhui Province, China.
出版信息
J Eur Acad Dermatol Venereol. 2007 May;21(5):602-5. doi: 10.1111/j.1468-3083.2006.02022.x.
BACKGROUND
Acne is a chronic inflammatory disease of the pilosebaceous follicles. Recent studies bring us increasing evidences that hereditary factors play an important but indirect role in acne.
OBJECTIVE
To investigate the possible role of genetic factors in the pathogenesis of acne vulgaris in Chinese Han ethnic group.
PATIENTS AND METHODS
Volunteers of 975 acne cases and 580 controls were included, contributing 3009 and 1825 first-degree relatives, respectively. One thousand and eighty-five first-degree relatives of acne cases were affected with facial acne. This compared with 223 first-degree relatives of non-acne controls. The odds ratio was used to estimate the relative risk for acne vulgaris associated with having an affected first-degree relative.
RESULTS
The risk of acne vulgaris occurring in a relative of a patient with acne vulgaris was significantly greater than for the relative of an unaffected individual (odds ratio 4.05, 95% confidence interval (CI): 3.45-4.76, P<0.001).
CONCLUSION
Our study suggests that familial factors are important in determining individual susceptibility to acne vulgaris.
背景
痤疮是一种毛囊皮脂腺的慢性炎症性疾病。最近的研究为我们提供了越来越多的证据，表明遗传因素在痤疮中起着重要但间接的作用。
目的
探讨遗传因素在寻常痤疮发病机制中的可能作用，研究对象为中国汉族人群。
患者与方法
纳入975例痤疮患者和580例对照志愿者，分别有3009名和1825名一级亲属。痤疮患者的1085名一级亲属患有面部痤疮，而非痤疮对照的一级亲属中有223名患有面部痤疮。采用比值比来估计有患病一级亲属的个体患寻常痤疮的相对风险。
结果
寻常痤疮患者亲属患寻常痤疮的风险显著高于未患病个体的亲属（比值比4.05，95%置信区间(CI)：3.45 - 4.76，P<0.001）。
结论
我们的研究表明，家族因素在决定个体对寻常痤疮的易感性方面很重要。
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