Department of Dermatology, No.1 Hospital of China Medical University; Shenyang, China.
J Eur Acad Dermatol Venereol. 2010 Aug;24(8):953-7. doi: 10.1111/j.1468-3083.2010.03590.x. Epub 2010 Mar 10.
Adolescent acne impacts self-esteem and quality of life in adolescents and its aetiology is not fully clarified.
The aim of this study was to describe the epidemiological features of adolescent acne in North East China and determine the impact of genetic and environmental factors on the pathogenesis of acne.
Data were collected from 5696 undergraduates (2920 patients and 2776 controls) using questionnaire. The survey data were analysed using spss version 13.0 and heritability of adolescent acne was calculated using Falconer's method.
Total prevalence of adolescent acne was 51.30% (52.74% in males, 49.65% in females). The difference between genders was statistically significant (P < 0.05). Adolescents with a family history of acne had earlier age of onset (P < 0.001). The prevalence of acne in first- and second-degree relatives of acne patients was 22.5% and 7.19%, respectively, significantly higher than in controls (P < 0.001). Heritability of adolescent acne was 78.47 +/- 2.05% in first-degree relatives and 75.05 +/- 3.18% in second-degree relatives. Risk factors to the acne suffers include (in descending order of occurrence), acne family history, mental stress, menstrual disorder, frequent insomnia, high fat diet, being male, dysmenorrhoea, anxiety, sleeping < 8 h per day, depression, fried food, study pressure, spicy food, oily skin and mixed type skin. Protective factors include (presented in descending order of occurrence) dry skin, neutral skin, frequent fruit consumption and computer access time < 2 h daily.
Adolescent acne includes a familial genetic predisposition. Additional environmental factors of psychological stress, skin oiliness and high caloric diets may also contribute to the onset of acne in Chinese adolescents.
青少年痤疮会影响青少年的自尊心和生活质量，但其病因尚未完全阐明。
本研究旨在描述中国东北地区青少年痤疮的流行病学特征，并确定遗传和环境因素对痤疮发病机制的影响。
采用问卷调查的方式，从 5696 名大学生（2920 例患者和 2776 例对照）中收集数据。使用 spss 版本 13.0 对调查数据进行分析，采用 Falconer 法计算青少年痤疮的遗传率。
青少年痤疮总患病率为 51.30%（男生为 52.74%，女生为 49.65%）。男女之间的差异有统计学意义（P < 0.05）。有痤疮家族史的青少年发病年龄更早（P < 0.001）。痤疮患者一级亲属和二级亲属中痤疮的患病率分别为 22.5%和 7.19%，明显高于对照组（P < 0.001）。青少年痤疮的遗传率在一级亲属中为 78.47% ± 2.05%，在二级亲属中为 75.05% ± 3.18%。痤疮患者的发病风险因素包括（按发生频率降序排列）：痤疮家族史、精神压力、月经失调、频繁失眠、高脂饮食、男性、痛经、焦虑、每天睡眠<8 小时、抑郁、油炸食品、学习压力、辛辣食物、油性皮肤和混合性皮肤。保护因素包括（按发生频率降序排列）：干性皮肤、中性皮肤、经常吃水果和每天使用电脑<2 小时。
青少年痤疮包括家族遗传易感性。心理应激、皮肤油性和高卡路里饮食等额外的环境因素也可能导致中国青少年痤疮的发生。
