Centro Studi Gruppo Italiano Studi Epidemiologici in Dermatologia, Fondazione per la Ricerca Ospedale Maggiore, Bergamo, Italy.
J Am Acad Dermatol. 2012 Dec;67(6):1129-35. doi: 10.1016/j.jaad.2012.02.018. Epub 2012 Mar 3.
Genetic and environmental components may contribute to acne causation.
We sought to assess the impact of family history, personal habits, dietary factors, and menstrual history on a new diagnosis of moderate to severe acne.
We conducted a case-control study in dermatologic outpatient clinics in Italy. Cases (205) were consecutive those receiving a new diagnosis of moderate to severe acne. Control subjects (358) were people with no or mild acne, coming for a dermatologic consultation other than for acne.
Moderate to severe acne was strongly associated with a family history of acne in first-degree relatives (odds ratio 3.41, 95% confidence interval 2.31-5.05). The risk was reduced in people with lower body mass index with a more pronounced effect in male compared with female individuals. No association with smoking emerged. The risk increased with increased milk consumption (odds ratio 1.78, 95% confidence interval 1.22-2.59) in those consuming more than 3 portions per week. The association was more marked for skim than for whole milk. Consumption of fish was associated with a protective effect (odds ratio 0.68, 95% confidence interval 0.47-0.99). No association emerged between menstrual variables and acne risk.
Some degree of overmatching may arise from choosing dermatologic control subjects and from inclusion of mild acne in the control group.
Family history, body mass index, and diet may influence the risk of moderate to severe acne. The influence of environmental and dietetic factors in acne should be further explored.
遗传和环境因素可能导致痤疮的发生。
我们旨在评估家族史、个人习惯、饮食因素和月经史对新诊断的中重度痤疮的影响。
我们在意大利的皮肤科门诊进行了病例对照研究。病例组(205 例)为连续新诊断为中重度痤疮的患者。对照组(358 例)为无或轻度痤疮患者,因非痤疮原因就诊皮肤科。
中重度痤疮与一级亲属的痤疮家族史密切相关(比值比 3.41,95%置信区间 2.31-5.05)。体重指数较低的人群风险降低,且男性的效果比女性更为明显。吸烟与痤疮无关。每周食用超过 3 份牛奶的人群(比值比 1.78,95%置信区间 1.22-2.59)风险增加,脱脂奶的关联比全脂奶更为显著。食用鱼与保护作用相关(比值比 0.68,95%置信区间 0.47-0.99)。月经变量与痤疮风险之间没有关联。
由于选择皮肤科对照和将轻度痤疮纳入对照组,可能存在一定程度的过度匹配。
家族史、体重指数和饮食可能影响中重度痤疮的风险。环境和饮食因素在痤疮中的影响应进一步探讨。