Slavik Tomas, Hannah Marius, Schroder Ralph A
Ampath Pathology Laboratories, Pretoria, South Africa.
J Cutan Pathol. 2007 May;34(5):427-30. doi: 10.1111/j.1600-0560.2006.00639.x.
Heterologous differentiation is exceedingly rare in melanoma. Only four cases of melanoma demonstrating exclusive cartilaginous differentiation have been documented, all having occurred on the lower extremity. We report a chondroid melanoma involving the nasal skin and presenting clinically as a basal cell carcinoma. Both Melan-A and microphthalmia transcription factor protein immunoperoxidase stains were positive in our case, demonstrating the potential utility of these two stains in chondroid melanoma. We also provide a succinct review of the literature on this rare melanoma variant.
异源性分化在黑色素瘤中极为罕见。仅有4例黑色素瘤表现为单纯软骨分化的病例被记录在案，所有这些病例均发生在下肢。我们报告1例累及鼻皮肤的软骨样黑色素瘤，临床上表现为基底细胞癌。在我们的病例中，Melan-A和小眼转录因子蛋白免疫过氧化物酶染色均呈阳性，表明这两种染色在软骨样黑色素瘤中的潜在应用价值。我们还对关于这种罕见黑色素瘤变体的文献进行了简要综述。
