雌激素受体与乳腺癌的自然病程。
Estrogen receptor and natural course of breast cancer.
作者信息
Singhakowinta A, Potter H G, Buroker T R, Samal B, Brooks S C, Vaitkevicius V K
出版信息
Ann Surg. 1976 Jan;183(1):84-8. doi: 10.1097/00000658-197601000-00017.
Abstract
The tumors from approximately 50% of patients with breast cancer contained estrogen receptor (ER). ER appeared more often and at higher levels in the tumors of postmenopausal women. Eleven out of 12 patients who had multiple ER assays from various metastatic sites showed no significant discrepancies in ER values. ER level appears to decrease as the duration of metastatic cancer increase. Patients with ER in the tumor more frequently have bone metastases than those without ER. Visceral metastases occurred more often with ER negative patients and appeared to have a more malignant course with significant shorter survival.
摘要
大约50%的乳腺癌患者肿瘤含有雌激素受体（ER）。ER在绝经后女性的肿瘤中出现得更频繁且水平更高。12例来自不同转移部位进行多次ER检测的患者中，有11例ER值无显著差异。随着转移性癌症病程延长，ER水平似乎会降低。肿瘤中有ER的患者比没有ER的患者更常发生骨转移。内脏转移在ER阴性患者中更常见，且似乎病程更凶险，生存期显著缩短。
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