Maass H, Engel B, Nowakowski H, Stolzenbach G, Trams G
Arch Geschwulstforsch. 1975;45(5):423-9.
Human breast cancer was studied by in vitro techniques on tissue slices and extracts for a specific binding of estradiol and dihydrotestosterone. Estradiol receptors were found in 50 percent of patients in the premenopausal group and in 47 percent of patients in the postmenopausal group. The incidence of receptors in patients with metastatic disease was 32.5 percent. In 18 of 35 patients who were positive for receptor sites a remission was observed after a variety of endocrine treatment regimens. In contrast only 3 patients out of 43 with a negative binding pattern responded to treatment with nafoxidine for a very short time. The best correlation was found in the ovariectomized group. Between the responders and the nonresonders there is no difference in the quantitative receptor content. The same is valid in view of the duration of the remission.
采用体外技术对人体乳腺癌组织切片和提取物进行研究，以检测雌二醇和双氢睾酮的特异性结合。绝经前组50%的患者和绝经后组47%的患者中发现了雌二醇受体。转移性疾病患者中受体的发生率为32.5%。在35例受体位点呈阳性的患者中，有18例在接受各种内分泌治疗方案后病情缓解。相比之下，43例结合模式呈阴性的患者中，只有3例对萘福昔定治疗有非常短暂的反应。在卵巢切除组中发现了最佳相关性。反应者和无反应者之间在受体定量含量上没有差异。就缓解期而言，情况也是如此。
