Kaviarasan S, Viswanathan P, Anuradha C V
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu 608 002, India.
Cell Biol Toxicol. 2007 Nov;23(6):373-83. doi: 10.1007/s10565-007-9000-7. Epub 2007 Apr 24.
Chronic alcoholism is associated with fatty liver and fibrosis characterized by collagen accumulation. Seeds of fenugreek, an annual herb, are reported to possess hepatoprotective activity. The study aims to investigate the effects of fenugreek seed polyphenol extract (FPEt) on liver lipids and collagen in experimental hepatotoxic rats. Hepatotoxicity was induced in male albino Wistar rats by administrating ethanol (6 g/kg per day) for 30 days. Control rats were given isocaloric glucose solution. FPEt was co-administered with ethanol at a dose of 200 mg/kg per day for the next 30 days. Silymarin was used as a positive control. Ethanol treatment caused increase in plasma and liver lipids, together with alterations in collagen content and properties. Administration of FPEt to alcohol-fed rats significantly improved lipid profile and reduced collagen content, crosslinking, aldehyde content and peroxidation. The effects were comparable with that of silymarin. FPEt administration had a positive influence on both lipid profile and on the quantitative and qualitative properties of collagen in alcoholic liver disease. The protective effect is presumably due to the bioactive phytochemicals in fenugreek seeds.
慢性酒精中毒与以胶原积累为特征的脂肪肝和肝纤维化有关。胡芦巴是一种一年生草本植物，其种子据报道具有肝脏保护活性。本研究旨在探讨胡芦巴种子多酚提取物（FPEt）对实验性肝毒性大鼠肝脏脂质和胶原的影响。通过给雄性白化Wistar大鼠每天灌胃乙醇（6克/千克），持续30天来诱导肝毒性。对照大鼠给予等热量的葡萄糖溶液。在接下来的30天里，将FPEt以每天200毫克/千克的剂量与乙醇共同给药。水飞蓟宾用作阳性对照。乙醇处理导致血浆和肝脏脂质增加，同时胶原含量和性质发生改变。给酒精喂养的大鼠施用FPEt可显著改善脂质谱并降低胶原含量、交联、醛含量和过氧化。这些效果与水飞蓟宾相当。施用FPEt对酒精性肝病的脂质谱以及胶原的定量和定性性质均有积极影响。这种保护作用可能归因于胡芦巴种子中的生物活性植物化学物质。
