Bentdal Yngvild E, Nafstad Per, Karevold Gunnhild, Kvaerner Kari J
Department of Otorhinolaryngology, Faculty Division of Akershus University Hospital, University of Oslo, Sykehusvagen 27, 1478 Lørenskog, Norway.
Acta Otolaryngol. 2007 May;127(5):480-5. doi: 10.1080/00016480600895128.
Single and repeated episodes of acute otitis media (AOM) in 10-year-old children were associated with reported allergic disease. Further, skin prick test (SPT)-negative children with reported asthma and allergic rhinoconjunctivitis had increased risk of AOM. We suggest that optimal treatment of allergic symptoms may have an effect on AOM in school children.
The objective of the study was to estimate associations between AOM, allergic diseases and SPT positivity in 10-year-old children.
Population-based cross-sectional study of 3406 10-year-old children living in Oslo. Main outcome measures were questionnaire-based information on AOM and reported physician-diagnosed allergic diseases with symptoms during the last year. In addition, 2657 children were skin prick tested. Logistic regression analyses were performed to estimate associations and control for potential confounders.
One or more episodes of AOM were present in 13.8% (n=470) of the children; 9.7% (n=331) had single episodes, while 4.1% (n=139) had two or more infections. We found a statistically significant association between AOM and reported allergic diseases, strongest for AOM and asthma with odds ratio 2.7 (95% confidence interval 1.8-4.0) and 2.3 (95% confidence interval 1.3-4.3) for single and two or more episodes of AOM, respectively. The risk for AOM was increased in asthmatic SPT-negative children compared with asthmatic SPT-positive children, the odds ratios were 3.0 (1.7-5.4) and 1.5 (0.8-2.8), respectively. The same tendency was found for allergic rhinoconjunctivitis.
10岁儿童单次及反复急性中耳炎（AOM）发作与所报告的过敏性疾病相关。此外，皮肤点刺试验（SPT）阴性但报告患有哮喘和变应性鼻结膜炎的儿童患AOM的风险增加。我们认为，最佳治疗过敏症状可能对学龄儿童的AOM有影响。
本研究的目的是评估10岁儿童中AOM、过敏性疾病和SPT阳性之间的关联。
对居住在奥斯陆的3406名10岁儿童进行基于人群的横断面研究。主要结局指标是基于问卷的关于AOM的信息以及过去一年中报告的经医生诊断的有症状的过敏性疾病。此外，对2657名儿童进行了皮肤点刺试验。进行逻辑回归分析以评估关联并控制潜在混杂因素。
13.8%（n = 470）的儿童有一次或多次AOM发作；9.7%（n = 331）为单次发作，而4.1%（n = 139）有两次或更多次感染。我们发现AOM与所报告的过敏性疾病之间存在统计学显著关联，AOM与哮喘的关联最强，单次AOM发作和两次或更多次AOM发作的比值比分别为2.7（95%置信区间1.8 - 4.0）和2.3（95%置信区间1.3 - 4.3）。与SPT阳性的哮喘儿童相比，SPT阴性的哮喘儿童患AOM的风险增加，比值比分别为3.0（1.7 - 5.4）和1.5（0.8 - 2.8）。变应性鼻结膜炎也有同样的趋势。
