Chen G, Zhu Y, Wang H-Z, Wang S-J, Zhang R-Q
Department of Biological Science and Biotechnology, Tsinghua University, Beijing, China.
J Asian Nat Prod Res. 2007 Mar;9(2):159-64. doi: 10.1080/10286020500480423.
The chemical constituents research of the fermentation of Penicillium thomi separated from the root of Bruguiera gymnorrhiza led to the isolation of a new compound, 4',5-dihydroxy-2,3-dimethoxy-4-(hydroxypropyl)-biphenyl (1) and 11 known compounds. The structures of isolated compounds were determined by spectroscopic and chemical analysis. Their cytotoxic effects against three human cancer cell lines (A549, HepG2 and HT29) were also investigated.
对从白骨壤根部分离得到的 Thomii 青霉发酵产物进行化学成分研究，从中分离得到一个新化合物 4',5-二羟基-2,3-二甲氧基-4-(羟丙基)-联苯(1)以及 11 个已知化合物。通过光谱和化学分析确定了分离得到化合物的结构。还研究了它们对三种人类癌细胞系(A549、HepG2 和 HT29)的细胞毒性作用。
