Li Chun-Yuan, Ding Wei-Jia, Shao Chang-Lun, She Zhi-Gang, Lin Yong-Cheng
Department of Applied Chemistry, College of Sciences, South China Agricultural University, Guangzhou 510642, China.
Zhong Yao Cai. 2008 Jul;31(7):960-2.
The metabolites of a marine mangrove fungus (Penicillium sp. No. 2556) were studied in this paper and six compounds were isolated from the fermentation liquid. Their structures were elucidated by spectroscopy methods as Sch54796 (1), Sch54794 (2), 4-hydroxybenzoic acid (3), urail (4), succinic acid (5), Vermopyrone (6). Among them, compounds 1, 2 and 6 were firstly isolated from Penicillium sp., Coumpounds 1 and 2 remarkably inhibited the growth of cancer cell lines hep2 and hepG2.
本文对一种海洋红树林真菌（青霉属2556号菌株）的代谢产物进行了研究，从发酵液中分离出6种化合物。通过光谱方法确定了它们的结构，分别为Sch54796（1）、Sch54794（2）、4 - 羟基苯甲酸（3）、尿嘧啶（4）、琥珀酸（5）、Vermopyrone（6）。其中，化合物1、2和6首次从青霉属中分离得到，化合物1和2对癌细胞系hep2和hepG2的生长具有显著抑制作用。
