超声评估胃黏膜血流的新方法。

New method of evaluating gastric mucosal blood flow by ultrasound.

作者信息

Mitsuoka Yutaka, Hata Jiro, Haruma Ken, Manabe Noriaki, Tanaka Shinji, Chayama Kazuaki

机构信息

Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.

出版信息

Scand J Gastroenterol. 2007 Apr;42(4):513-8. doi: 10.1080/00365520600955021.

DOI:10.1080/00365520600955021

PMID:17454863

Abstract

OBJECTIVE

Evaluation of gastrointestinal blood flow is important. However, a non-invasive measurement method has not yet been established. The aim of this study was to compare measurement of normal gastric mucosal blood flow by advanced dynamic flow (ADF) flash echo imaging (FEI) with intravenous Levovist with measurement by laser Doppler flowmetry (LDF) to clarify the usefulness of ADF-FEI and thereby consider its feasibility as a non-invasive gastric mucosal blood flow measurement method.

MATERIAL AND METHODS

Measurements were obtained in 25 beagle dogs (8-month-old males, body-weight, 10.6+/-1.3 kg, mean+/-SD). After insertion of a gastrointestinal endoscope, gastric mucosal blood flow at the greater curvature of the corpus was measured by LDF, and images of gastric mucosal blood flow were obtained by ADF-FEI (frequency; 4.7 MHz) with intravenous injection of Levovist (30 mg/kg). ADF-FEI images were transferred to a personal computer. A region of interest was set on the mucosa of the greater curvature of the corpus, and a time intensity curve (TIC) was plotted from the measured echo intensities. The area under the curve (AUC) calculated from the TIC and the median flow determined by LDF were analyzed and compared.

RESULTS

Evaluation of normal gastric mucosal blood flow by ADF-FEI was possible in all animals. There was a strong, significant correlation between gastric mucosal blood flow measured by LDF and the AUC obtained by ADF-FEI (r=0.869, p<0.0001).

CONCLUSIONS

Gastric mucosal blood flow can be accurately measured by ADF-FEI with intravenous Levovist injection.

摘要

目的

评估胃肠道血流很重要。然而，尚未建立非侵入性测量方法。本研究的目的是比较先进动态血流（ADF）闪光回声成像（FEI）联合静脉注射Levovist测量正常胃黏膜血流与激光多普勒血流仪（LDF）测量结果，以阐明ADF-FEI的实用性，从而考虑其作为非侵入性胃黏膜血流测量方法的可行性。

材料与方法

对25只比格犬（8月龄雄性，体重10.6±1.3 kg，平均值±标准差）进行测量。插入胃肠内窥镜后，用LDF测量胃体大弯处的胃黏膜血流，静脉注射Levovist（30 mg/kg）后用ADF-FEI（频率；4.7 MHz）获取胃黏膜血流图像。ADF-FEI图像传输至个人电脑。在胃体大弯处的黏膜上设置感兴趣区域，并根据测量的回声强度绘制时间强度曲线（TIC）。分析并比较由TIC计算得出的曲线下面积（AUC）和LDF测定的平均血流。