Yang Xiaoming
Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Radiology. 2007 May;243(2):340-7. doi: 10.1148/radiol.2432060307.
The rapid progress of nanoscience and the application of nanotechnology are changing the foundations of diagnosis, treatment, and prevention of cardiovascular diseases. As the core of nanotechnology, nano- and microparticles offer "three-in-one" functions as imaging agents, target probes, and therapeutic carriers. While nano- and microparticle-based imaging of cardiovascular interventions is still in its developing phase, it has already presented the exciting potential to monitor primary interventional procedures for precise therapeutic delivery, enhance the effectiveness of delivered therapeutics, and monitor therapeutic efficiency after interventions performed to treat cardiovascular diseases. This article provides an overview of the current status of the application of nano- and microparticles in the imaging of cardiovascular interventions.
纳米科学的迅速发展和纳米技术的应用正在改变心血管疾病诊断、治疗和预防的基础。作为纳米技术的核心,纳米颗粒和微米颗粒具有成像剂、靶向探针和治疗载体的“三合一”功能。虽然基于纳米颗粒和微米颗粒的心血管介入成像仍处于发展阶段,但它已经展现出令人兴奋的潜力,可用于监测主要介入程序以实现精确治疗递送、提高递送治疗药物的有效性,以及在进行治疗心血管疾病的干预后监测治疗效果。本文概述了纳米颗粒和微米颗粒在心血管介入成像中的应用现状。