Alharbi Khalid Khalaf, Al-Sheikh Yazeed A
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, P.O. Box 10219, Riyadh 11433, Saudi Arabia.
Saudi J Biol Sci. 2014 Apr;21(2):109-17. doi: 10.1016/j.sjbs.2013.11.001. Epub 2013 Nov 19.
Nanodiagnostics is the term used for the application of nanobiotechnology in molecular diagnosis, which is important for developing personalized cancer therapy. It is usually based on pharmacogenetics, pharmacogenomics, and pharmacoproteomic information but also takes into consideration environmental factors that influence response to therapy. Nanotechnology in medicine involves applications of nanoparticles currently under development, as well as longer range research that involves the use of manufactured nano-robots to make repairs at the cellular level. Nanodiagnostic technologies are also being used to refine the discovery of biomarkers, as nanoparticles offer advantages of high volume/surface ratio and multifunctionality. Biomarkers are important basic components of personalized medicine and are applicable to the management of cancer as well. The field of nano diagnostics raises certain ethical concerns related with the testing of blood. With advances in diagnostic technologies, doctors will be able to give patients complete health checks quickly and routinely. If any medication is required this will be tailored specifically to the individual based on their genetic makeup, thus preventing unwanted side-effects.
纳米诊断学是指纳米生物技术在分子诊断中的应用,这对于开发个性化癌症治疗方法非常重要。它通常基于药物遗传学、药物基因组学和药物蛋白质组学信息,但也会考虑影响治疗反应的环境因素。医学中的纳米技术涉及目前正在开发的纳米颗粒的应用,以及涉及使用人造纳米机器人在细胞水平进行修复的更长远研究。纳米诊断技术也被用于优化生物标志物的发现,因为纳米颗粒具有高体积/表面积比和多功能性的优势。生物标志物是个性化医疗的重要基本组成部分,也适用于癌症管理。纳米诊断领域引发了一些与血液检测相关的伦理问题。随着诊断技术的进步,医生将能够快速且常规地为患者进行全面的健康检查。如果需要任何药物治疗,将根据患者的基因构成专门定制,从而预防不必要的副作用。