Cywińska Monika A, Grudziński Ireneusz P, Cieszanowski Andrzej, Bystrzejewski Michał, Popławska Magdalena
Faculty of Pharmacy, Toxicology Division, Medical University of Warsaw, Warsaw, Poland.
Pol J Radiol. 2011 Apr;76(2):28-36.
The application of biomedical nanotechnology in magnetic resonance imaging (MRI) is expect to have a major impact leading to the development of new contrast drug candidates on the nanoscale (1-100 nm) that are able to react with specific biological targets at a molecular level. One of the major challenges in this regard is the construction of nanomaterials, especially used in molecular MRI diagnostics of cancer in vivo, specialized antitumor drug delivery or real-time evaluation of the efficacy of the implemented cancer treatment. In this paper, we tried to gain further insights into current trends of nanomedicine, with special focus on preclinical MRI studies in translation cancer research.
生物医学纳米技术在磁共振成像(MRI)中的应用有望产生重大影响,从而推动新型纳米级(1-100纳米)造影剂候选药物的开发,这些药物能够在分子水平上与特定生物靶点发生反应。在这方面的主要挑战之一是纳米材料的构建,特别是用于体内癌症分子MRI诊断、专门的抗肿瘤药物递送或对实施的癌症治疗效果进行实时评估。在本文中,我们试图进一步深入了解纳米医学的当前趋势,特别关注转化癌症研究中的临床前MRI研究。