Dowse R, Futter W T
School of Pharmaceutical Sciences, Rhodes University, Grahamstown.
S Afr Med J. 1991 Dec 7;80(11-12):550-3.
Poor compliance with prescribed medication is a significant problem in chronic disease states and is often responsible for the apparent failure of therapy. The determinants and extent of non-compliance are commonly incorrectly perceived by doctors. During routine therapeutic drug monitoring of epileptic and asthmatic outpatients at a local day hospital, non-compliance was identified as a significant problem. A compliance study was conducted on 80 epileptic and asthmatic patients to determine the nature and extent of this problem. Non-compliance was measured using four different methods, which were then compared using chi 2 tests. Overall incidence of non-compliance was found to be 63%. Age, sex, standard of education and duration of disease were found to have no association with non-compliance. The most clinically significant finding was that almost half the patients were unaware of the necessity of taking their medication on a continuous basis. No significant differences existed between assessing non-compliance using tablet counts, patient interview and clinic attendance, whereas the method using blood levels gave significantly different results from all the other methods used.
在慢性病状态下，对规定药物的依从性差是一个重大问题，并且常常是治疗看似失败的原因。医生通常会错误地认识不依从的决定因素和程度。在当地日间医院对癫痫和哮喘门诊患者进行常规治疗药物监测期间，发现不依从是一个重大问题。对80名癫痫和哮喘患者进行了一项依从性研究，以确定该问题的性质和程度。使用四种不同方法测量不依从性，然后使用卡方检验进行比较。发现总体不依从发生率为63%。发现年龄、性别、教育水平和疾病持续时间与不依从无关。最具临床意义的发现是，几乎一半的患者没有意识到持续服药的必要性。使用药片计数、患者访谈和门诊就诊评估不依从性之间没有显著差异，而使用血药浓度的方法与所有其他使用的方法得出的结果有显著差异。
