Scott Bobby R
Lovelace Biomedical Research Institute, Albuquerque, NM, USA.
Dose Response. 2025 Mar 27;23(1):15593258251318305. doi: 10.1177/15593258251318305. eCollection 2025 Jan-Mar.
We are exposed to natural ionizing radiation and other genomic stressors throughout life and radiophobia has caused much harm to society. The main basis for radiophobia is the invalid linear no-threshold (LNT) hypothesis for cancer induction, which the System of Radiological Protection (SRP) is linked to. Largely unknown to the public, evolution-associated over many previous generations now provides protection to all lifeforms from low radiation doses. To help bring about an improved SRP not linked to the invalid LNT hypothesis for radiation-caused health detriment and to promote low-dose radiation therapy for different diseases. All-solid-cancer mortality risk dose-response relationships for A-bomb survivors were generated based on published LNT-modeling-related results. Dose-response relationships for lung cancer prevention by low-dose radiation were generated by linear interpolation based on published data from a study using > 15,000 mice. Uncertainty characterization was based on Monte Carlo calculations for binomial and Poisson distributions. New dose characterization tools were used for threshold dose-response relationships for radiation-caused cancer mortality. The all-solid-cancer mortality risk for A-bomb survivors transitioned from LNT to threshold-linear when adjusted for key missing uncertainty at low doses. The prevention of lung cancer in mice by low radiation doses depends on the radiation absorbed dose and type. The SRP should be linked to population dose thresholds rather than the invalid LNT hypothesis and small likely harmless radiation doses could possibly be used in treating different diseases.
我们在一生中都会接触到天然电离辐射和其他基因组应激源,而辐射恐惧症已对社会造成了诸多危害。辐射恐惧症的主要依据是用于致癌的无效线性无阈(LNT)假说,放射防护体系(SRP)与之相关。公众大多并不知晓,历经许多代进化如今为所有生命形式提供了对低辐射剂量的保护。为了促成一个与辐射所致健康损害的无效LNT假说无关的改进版SRP,并推动针对不同疾病的低剂量放射治疗。基于已发表的与LNT建模相关的结果,生成了原子弹幸存者的全实体癌死亡率风险剂量反应关系。通过对一项使用超过15000只小鼠的研究的已发表数据进行线性插值,生成了低剂量辐射预防肺癌的剂量反应关系。不确定性表征基于二项分布和泊松分布的蒙特卡罗计算。新的剂量表征工具被用于辐射所致癌症死亡率的阈值剂量反应关系。当针对低剂量时关键的缺失不确定性进行调整后,原子弹幸存者的全实体癌死亡率风险从LNT转变为阈值线性。低剂量辐射对小鼠肺癌的预防取决于辐射吸收剂量和类型。SRP应与人群剂量阈值相关联,而非无效的LNT假说,并且小剂量可能无害的辐射剂量有可能用于治疗不同疾病。