Mobbs Ralph J, Dvorak Marcel
Prince of Wales Hospital, Peripheral Nerve Research Foundation, 3 Wansey Road, Randwick, New South Wales 2031, Australia.
J Clin Neurosci. 2007 Jul;14(7):703-5. doi: 10.1016/j.jocn.2006.01.010. Epub 2007 Apr 24.
Ossified ligamentum flavum (OLF) is being appreciated as an important cause of thoracic myeloradiculopathy. However, despite numerous epidemiological and basic science studies, the pathogenesis of OLF has not been conclusively established. Ossification and symptom development are significantly more frequent in the Japanese population, therefore supporting a genetic predilection for the disease process. We present an unusual case of OLF in a patient from a low-risk genetic background (Chinese), exposed in youth to a lifestyle and diet from a high-risk population (Japanese). Based on our case report, we support the view that dietary habits may constitute an independent risk factor for OLF and ossification of the posterior longitudinal ligament.
骨化的黄韧带（OLF）被认为是胸段脊髓神经根病的一个重要病因。然而，尽管有大量的流行病学和基础科学研究，但OLF的发病机制尚未最终确定。骨化和症状发展在日本人群中明显更为常见，因此支持该病过程存在遗传易感性。我们报告了一例来自低风险遗传背景（中国人）的患者发生OLF的不寻常病例，该患者在年轻时接触了高风险人群（日本人）的生活方式和饮食。基于我们的病例报告，我们支持饮食习惯可能构成OLF和后纵韧带骨化独立危险因素的观点。
