Cabungcal Jan-Harry, Preissmann Delphine, Delseth Caroline, Cuénod Michel, Do Kim Q, Schenk Françoise
Department of Physiology, University of Lausanne, CH-1005 Lausanne, Switzerland.
Neurobiol Dis. 2007 Jun;26(3):634-45. doi: 10.1016/j.nbd.2007.03.001. Epub 2007 Mar 14.
Glutathione (GSH) metabolism dysfunction is one risk factor in schizophrenia. A transitory brain GSH deficit was induced in Wistar (WIS) and mutant (ODS; lacking ascorbic acid synthesis) rats using BSO (l-buthionine-(S,R)-sulfoximine) from post-natal days 5-16. When GSH was re-established to physiological levels, juvenile BSO-ODS rats were impaired in the water maze task. Long after treatment cessation, adult BSO-WIS/-ODS rats showed impaired place discrimination in the homing board with distributed visual or olfactory cues. Their accuracy was restored when a single cue marked the trained position. Similarly, more working memory errors were made by adult BSO-WIS in the radial maze when several olfactory cues were present. These results reveal that BSO rats did not suffer simple sensory impairment. They were selectively impaired in spatial memory when the task required the integration of multimodal or olfactory cues. These results, in part, resemble some of the reported olfactory discrimination and cognitive impairment in schizophrenia.
谷胱甘肽（GSH）代谢功能障碍是精神分裂症的一个风险因素。从出生后第5天到第16天，使用丁硫氨酸-（S，R）-亚砜胺（BSO）在Wistar（WIS）大鼠和突变型（ODS；缺乏抗坏血酸合成）大鼠中诱导短暂的脑GSH缺乏。当GSH恢复到生理水平时，幼年BSO-ODS大鼠在水迷宫任务中受损。在停止治疗很久之后，成年BSO-WIS/ -ODS大鼠在带有分布式视觉或嗅觉线索的归巢板中表现出位置辨别能力受损。当单个线索标记训练位置时，它们的准确性得以恢复。同样，当存在多个嗅觉线索时，成年BSO-WIS大鼠在放射状迷宫中会出现更多工作记忆错误。这些结果表明，BSO大鼠并非遭受简单的感觉障碍。当任务需要整合多模式或嗅觉线索时，它们在空间记忆方面存在选择性受损。这些结果部分类似于精神分裂症中报道的一些嗅觉辨别和认知障碍。
