van Hateren J H, Snippe H P
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
J Vis. 2007 Mar 5;7(4):1. doi: 10.1167/7.4.1.
A computational model of human cones for intensities ranging from 1 td up to full bleaching levels is presented. The model conforms well with measurements made in primate horizontal cells, follows Weber's law at high intensities, and performs range compression consistent with what is known of cones in other vertebrates. The model consists entirely of processes with a clear physiological interpretation: pigment bleaching, saturation of cGMP hydrolysis, calcium feedback on cGMP synthesis, and a nonlinear membrane. The model is implemented according to a very fast computational scheme useful for simulations, and sample programs in Matlab and Fortran are provided as supplementary material.
本文提出了一种针对强度范围从1 td到完全漂白水平的人类视锥细胞计算模型。该模型与在灵长类水平细胞中进行的测量结果高度吻合，在高强度下遵循韦伯定律，并执行与其他脊椎动物视锥细胞已知情况一致的范围压缩。该模型完全由具有明确生理学解释的过程组成：色素漂白、cGMP水解的饱和、cGMP合成中的钙反馈以及非线性膜。该模型根据一种非常快速的计算方案实现，适用于模拟，并提供了Matlab和Fortran的示例程序作为补充材料。
